Someone makes a post about "tech savvy people here" and yet no one understands the NTFS file system?? Sheesh.
The main benefit you lose here is speed. When your system is idle, NTFS will relocate files that are often written to/read from to the inside of the HDD's physical platters where seek times are the lowest. Inversely, files that are read from to load applications, along with any other large files are arranged so that the files are contiguous. These are also placed on the outside of the physical platters where transfer speeds are the greatest.