I've been testing F-Secure Internet Security 2006 and it looks to me like a suitable program. It is quite advanced in certain aspects but still simple enough for anyone to use. In short the features are:
- Anti-Virus - protects against viruses, trojans and other peskywares
- Anti-Spyware - no spyware, adware, whatever you call it
- Anti-Rootkit - no Sony "we own you and your CD" rootkits are undetectable to this scanner
- Firewall - lets me know when someone scans my ports as a bonus
- Spam filter - works nicely, together with Outlook 2003
- Parential control - can be turned off, since you might not need it
Plus, F-Secure is among the fastest in releasing protection updates for viruses according to some study I saw. (That is the reason I switched from Symantec and I still thank my gods for doing myself that favor at every worm outbreak.

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It works nicely out of the box with ActiveSync and requires little configuraion to work IMO. The spam part doens't catch everything, but it catches the emails that Outlook doesn't.
But, in the end, you decide which to choose. Be sure to check out
AV-test.org where they test the update response and such of different virus companies. You might also be interested in a review of
F-Secure IS 2006 by PCMag, as well as look at
the other anti-virus options while you're there.