"TweetDeck is one of the most popular Twitter clients, and with the bevy of features, support for multiple accounts and services - plus groups - TweetDeck has defined itself as a solid cross-platform Twitter client for the power user."
I switch around on what I use for Twitter from my desktop, and this is one of the programs that I keep in the mix. Now they have integrated keyboard command and control with this version, along with some other nice features such as newest followers in it's own group and notification changes. Not essential additions, but some that are handy.
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iPhone 4, 1.6 GHz Core 2 Duo MacBook Air, Apple TV, 2.66GHz Intel C2D Mac Mini, 1TB TC, Airport Extreme,several iPods and an iPad, 32GB Wi-Fi version. Follow me on Twitter.