Most CF gps card can run without additional drivers.
http://www.pharosgps.com/products/la...Misc/PF063.htm This is the pharos one which shouldn't need drivers since they don't seem to ship a driver disk with it.
Oh yeah! use MS street and trips 2004 or higher. When attempting to configure MS s&t 2003, I came across a help file note that said CF GPS cards create a "virtual" com port that is not currently supported.