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Tweetdeck on the Mac / Winders, particularly the new version with Facebook statuses.
Twittelator Pro on the iPhone. Nothing I've used matches the featureset. It isn't the snappiest of performers, but the way it integrates replies, works with Twitpic, and its overall robustness basically keeps it a fixture there.
On my BlackBerry I use Twitterberry, but that ain't sayin' much because I don't think there's even anything else out there.
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Current Apple Stuff: 24" iMac, iPhone 4, AppleTV (original), 4gb Shuffle, 64gb iPad 2.
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