I have four active POP3 email accounts and one IMAP. I manage each one differently. The IMAP (for my "day job") is easiest since I can have my desktop automatically download messages and still be able to see them on my Windows Mobile device. For the most of the POP3, I don't use automatic downloads any more. I check them periodically throughout the day either on my desktop or on my WM device depending on where I am at the moment. If I'm mobile, I use the phone to delete any messages that are SPAM or I don't need to save so that the desktop downloads are reduced.
Finally, one of my POP accounts gets LOTS of SPAM. I use the desktop to automatically download that one, since there's never anything urgent sent there anyway. If I need to check that one while I'm mobile, I use the WM version of GoToMyPC to view Outlook on the desktop.
In any case, my email is way too complicated and takes way too much of my time these days.
